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Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible. [1] Symptoms include muscle rigidity , fever , and a fast heart rate . [ 1 ]
The presence of signs and symptoms related to hyperthermia syndromes, such as extrapyramidal symptoms characteristic of neuroleptic malignant syndrome, and the absence of signs and symptoms more commonly related to infection-related fevers, are also considered in making the diagnosis.
There is no specific treatment for central core disease. Certain triggering anesthetics must be avoided, and relatives should be screened for RYR1 mutations that cause malignant hyperthermia. [2] Research has shown that some patients may benefit from treatment with oral salbutamol. [6] [7]
Malignant hyperthermia: Ligand-gated calcium channel Mucolipidosis type IV: Non-selective cation channel Myotonia congenita: Voltage-dependent chloride channel Neuromyelitis optica: Aquaporin-4 water channel Neuromyotonia: Voltage-gated potassium channel Nonsyndromic deafness: various Paramyotonia congenita (a periodic paralysis) Voltage-gated ...
Neuroleptic malignant syndrome; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics) e.g. Haloperidol, Chlorpromazine Serotonin syndrome ; excessive serotonergic activity due usually to combined use of serotonergic drugs ( e.g. antidepressants , stimulants , triptans )
Onset of symptoms is typically within a day of the extra serotonin. [2] Diagnosis is based on a person's symptoms and history of medication use. [2] Other conditions that can produce similar symptoms such as neuroleptic malignant syndrome, malignant hyperthermia, anticholinergic toxicity, heat stroke, and meningitis should be ruled out. [2]
Ben Tarver’s night terrors were the first symptoms of Anti-NMDA Receptor Encephalitis, a rare autoimmune disorder that landed him in the ICU 29-Year-Old in ‘Catatonic State’ After Rare ...
Sepsis, encephalitis, neuroleptic malignant syndrome, [8] malignant hyperthermia, [8] lethal catatonia, spinal cord injury (not associated with PSH), seizures, and hydrocephalus (this can be associated with PSH) are examples of diagnoses that should be considered due to the manifestation of similar symptoms before confirming a diagnosis of PSH. [3]