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Neural stem cells (NSCs) ... For neurodegenerative diseases, another transplantation therapy arising in research is the directional induction of neural stem cells. [23]
Neural stem cells (NSCs) in the brain must find a balance between maintaining their multipotency by self renewing and proliferating as opposed to differentiating and becoming quiescent. The PI3K/AKT pathway is crucial in this decision making process. NSCs are able to sense and respond to changes in the brain or throughout the organism.
Before implantation, the NSCs were treated with neurogenin 2 protein to encourage the proliferation of the intended inner ear cells. They concluded that adult NSCs were indeed able to survive and differentiate in the injured inner ear and that this type of therapy could act to restore auditory function in hearing-impaired subjects.
The axolotl is less commonly used than other vertebrates, but is still a classical model for examining regeneration and neurogenesis. Though the axolotl has made its place in biomedical research in terms of limb regeneration, [19] [20] the model organism has displayed a robust ability to generate new neurons following damage.
The NSCs work has been expanded by establishing a human inducible pluripotent cells platform. SWADESH: This was developed as an advanced automated neuro-tool to aid the early diagnosis of AD. This tool consists of several computer-assisted tools for data pre-processing, quality control, data preparation, analysis, evaluation, and assessment.
Vagus nerve stimulation therapy improved the symptoms of treatment-resistant depression for nearly 500 participants in a major clinical trial.