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Causes: Volatile anesthetic agents or succinylcholine in ... the propensity for malignant hyperthermia is due to a mutation of ... that is the hallmark of the disease.
The diagnosis is suggested on patients with a history of drug exposure to the most common inducing agents such as strong antidopaminergic medications. [6] [40] The differential diagnosis includes serotonin syndrome, [41] encephalitis, toxic encephalopathy, status epilepticus, heat stroke, catatonia and malignant hyperthermia.
Drug-induced fever is a symptom of an adverse drug reaction wherein the administration of drugs intended to help a patient causes a hypermetabolic state resulting in fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism , evoke a cellular or humoral immune response , mimic endogenous pyrogen , or ...
RyR1 mutations are associated with malignant hyperthermia and central core disease. [17] Mutant-type RyR1 receptors exposed to volatile anesthetics or other triggering agents can display an increased affinity for cytoplasmic Ca 2+ at activating sites as well as a decreased cytoplasmic Ca 2+ affinity at inhibitory sites. [18]
Recreational drugs such as amphetamines [17] and cocaine, [18] PCP, dextromethorphan, LSD, and MDMA may cause hyperthermia. [2] Malignant hyperthermia is a rare reaction to common anesthetic agents (such as halothane) or the paralytic agent succinylcholine. Those who have this reaction, which is potentially fatal, have a genetic predisposition. [2]
Ischemic heart disease. An adrenal gland tumor known as pheochromocytoma. Kidney failure or another condition that requires dialysis. A recent history of heart attack. Low blood pressure.
It may also occur due to an overdose of a single serotonergic agent. [29] The combination of monoamine oxidase inhibitors (MAOIs) with precursors such as L-tryptophan or 5-hydroxytryptophan pose a particularly acute risk of life-threatening serotonin syndrome. [ 30 ]
One tablespoon contains 14 grams of healthy fat—including mono- and polyunsaturated types, which help keep cholesterol levels in check and protect against heart disease.