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A549 cells are adenocarcinomic human alveolar basal epithelial cells, and constitute a cell line that was first developed in 1972 by D. J. Giard, et al. through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58-year-old caucasian male. [1]
An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore be grown for prolonged periods in vitro. The mutations required for immortality can occur ...
A549 may refer to: A549 (cell line), a carcinomic human alveolar basal epithelial cell; A549 road (Wales), a road in Great Britain This page was last edited on 27 ...
SEM image of syncytial virions taken from A549 cells in the lung epithelium. Following injury to airway epithelium, the basal cells can become infected by the respiratory syncytial virus. When this happens the basal cell can be skewed to favour the differentiation of mucus-producing (secretory goblet cells) over that of
The efficacy of two known PFKFB3 inhibitors, namely AZ67 (from AstraZeneca and CRT Discovery Laboratories [26]), and PFK158, an improved but structurally close derivative of 3PO, were recently investigated for their ability to reduce F2,6BP production in A549 cells. Both compounds (AZ67 and PFK158) were able to reduce the cellular levels of F2 ...
C) A549 cells treated with a short hairpin RNA that knocked down their levels of SUCNR1 had significantly reduced migration responses to succinate. D) A549 cells treated with succinate showed increases in SNAI1, a transcription factor that promotes EMT. E) Metformin (which is an inhibitor of EMT [72]) abolished the migration responses of A549 ...
This page was last edited on 23 November 2019, at 17:55 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
A549 cells share the same characteristics with the alveolar type II cells. This are type II pneumocytes crucial for lung homeostasis, and regeneration upon damage. For research purposes to unravel different molecular mechanisms leading to lung diseases, A549 cells serves as a good model to which translational research can be relied upon.