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Proliferating supporting cells can acquire hair cell fate in mitotic division. The mouse's neonatal supporting cells proliferate after hair cell death and regenerate hair cells after damage. [26] The neonatal cochlea is resistant to hair cell damage caused by exposure to noise or drugs, which are toxic to the cochlea, or auditory nerve, in vivo ...
The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
The supporting cells are differentiated from the hair cells, when early embryonic hair cells express ligands that bind to the Notch receptors would prevent them from obtaining the hair cell phenotype, and these cells would differentiate into supporting cells, this is one of the reasons that the supporting cells are able to regenerate new hair ...
Hair cell regeneration using stem cell and gene therapy is years or decades away from being clinically feasible. [28] However, studies are currently underway on the subject, with the first FDA-approved trial beginning in February 2012. [29]
The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2] Strategically positioned on the basilar membrane of the organ of Corti are three rows of outer hair cells (OHCs) and one row of inner hair cells ...
For one, the tall hair cell is very similar in function to that of the inner hair cell, and the short hair cell, lacking afferent auditory-nerve fiber innervation, resembles the outer hair cell. One unavoidable difference, however, is that while all hair cells are attached to a tectorial membrane in birds, only the outer hair cells are attached ...
The retinoblastoma protein is involved in the growth and development of mammalian hair cells of the cochlea, and appears to be related to the cells' inability to regenerate. Embryonic hair cells require pRb, among other important proteins, to exit the cell-cycle and stop dividing, which allows maturation of the auditory system.
To date, it has been found in the central nervous system in inner ear hair cells and retinal ganglion cells. Oncomodulin promotes axon regeneration in retinal ganglion cells [ 1 ] and maintains functioning in mouse cochlear hair cells.
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