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Mevalonate pathway diagram showing the conversion of acetyl-CoA into isopentenyl pyrophosphate, the essential building block of all isoprenoids. The eukaryotic variant is shown in black. Archaeal variants are shown in red and blue.
This diagram uses embedded text that can be easily translated using a text editor. Captions. English. ... Mevalonate pathway: Width: 744.09448819: Height: 1052.3622047
Isopentenyl pyrophosphate (IPP, isopentenyl diphosphate, or IDP) [1] is an isoprenoid precursor. IPP is an intermediate in the classical, HMG-CoA reductase pathway (commonly called the mevalonate pathway) and in the non-mevalonate MEP pathway of isoprenoid precursor biosynthesis.
In the final step of mevalonate biosynthesis, HMG-CoA reductase, an NADPH-dependent oxidoreductase, catalyzes the conversion of HMG-CoA into mevalonate, which is the primary regulatory point in this pathway. Mevalonate serves as the precursor to isoprenoid groups that are incorporated into a wide variety of end-products, including cholesterol ...
Mevalonic acid is a precursor in the biosynthetic pathway known as the mevalonate pathway that produces terpenes and steroids. Mevalonic acid is the primary precursor of isopentenyl pyrophosphate (IPP), that is in turn the basis for all terpenoids. Mevalonic acid is chiral and the (3R)-enantiomer is the only one that is biologically active.
5-Diphosphomevalonic acid (or mevalonate-5-pyrophosphate, or 5-pyrophosphomevalonate) is an intermediate in the mevalonate pathway. Mevalonate pathway. See also
1 Annotating the mevalonate pathway and usage in 3 articles. 2 comments Toggle Annotating the mevalonate pathway and usage in 3 articles subsection. 1.1 Section reflist.
Mevalonate pathway. The mevalonate pathway is also used in higher order eukaryotes and plants. Mevalonate diphosphate decarboxylase is mainly present in the liver of mammals where the majority of mevalonate is converted to cholesterol. [10] [11] Some of the cholesterol is converted to steroid hormones, bile acids, and vitamin D. [10]