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The Antimicrobial peptide databases may be divided into two categories on the basis of the source of peptides it contains, as specific databases and general databases. These databases have various tools for antimicrobial peptides analysis and prediction.
MethBase: database of DNA methylation data visualized on the UCSC Genome Browser; Minimotif Miner: database of short contiguous functional peptide motifs; Oncogenomic databases: a compilation of databases that serve for cancer research; PubMed: references and abstracts on life sciences and biomedical topics; RIKEN integrated database of mammals
AMDD otherwise known as Antimicrobial Drug Database is a biological database that seeks to consolidate antibacterial and antifungal drug information from a variety of sources such as PubChem, PubChem Bioassay, ZINC, ChemDB and DrugBank in order to advance the field of treatment of resistance microbes.
At present, the widespread spread of antibiotic resistance requires the search and development of new antimicrobial drugs. From this point of view, defensins (as well as antimicrobial peptides in general) are of great interest. It was shown that defensins have pronounced antibacterial activity against a wide range of pathogens. [50]
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The Comprehensive Antibiotic Resistance Database (CARD) is a biological database that collects and organizes reference information on antimicrobial resistance genes, proteins and phenotypes. [ 1 ] [ 2 ] The database covers all types of drug classes and resistance mechanisms and structures its data based on an ontology.
Cecropins are antimicrobial peptides. [1] [2] They were first isolated from the hemolymph of Hyalophora cecropia, whence the term cecropin was derived.Cecropins lyse bacterial cell membranes; they also inhibit proline uptake and cause leaky membranes.
The PhoPQ system, which detects similar situations and the presence of antimicrobial peptides, can also cross-trigger PmrA via a PmrD connector. Antibiotic resistance can occur when this system, or its upstream signals, mutates to become constitutively active. [10]