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MammaPrint is a prognostic and predictive diagnostic test for early stage breast cancer patients that assess the risk that a tumor will metastasize to other parts of the body. [1] It gives a binary result, high-risk or low-risk classification , and helps physicians determine whether or not a patient will benefit from chemotherapy .
Women who are A–T carriers (who have one mutated copy of the ATM gene) have approximately a two-fold increased risk for the development of breast cancer compared to the general population. [19] [20] This includes all mothers of A–T children and some female relatives. The current consensus is that special screening tests are not helpful, but ...
According to COSMIC, the Catalogue Of Somatic Mutations In Cancer, the frequencies with which heterozygous mutations in ATM are found in common cancers include 0.7% in 713 ovarian cancers, 0.9% in central nervous system cancers, 1.9% in 1,120 breast cancers, 2.1% in 847 kidney cancers, 4.6% in colon cancers, 7.2% among 1,040 lung cancers and 11 ...
Most cancer isn't caused by BRCA mutations — they account for 5 percent to 10 percent of breast cancers and 15 percent of ovarian cancers — so the gene tests aren't for everyone. But mutations ...
For example, the ColoGuard test may be used to screen people over 55 years old for colorectal cancer. [57] Cancer is a longtime-scale disease with various progression steps, molecular diagnostics tools can be used for prognosis of cancer progression. For example, the OncoType Dx test by Genomic Health can estimate risk of breast cancer.
Dr. Daniel Kopans is a leading expert in breast cancer detection and diagnosis. He is the founder of the Breast Imaging Division in the Department of Radiology at the Massachusetts General Hospital. In 1984 he was the lead author on a paper in the New England Journal of Medicine describing the developing subspecialty of "Breast Imaging".
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