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Low intensity pulsed ultrasound has been proposed as a therapy to support bone healing after fractures, [1] osteomies, or delayed healing. A 2017 review, however, found no trustworthy evidence for the use of low intensity pulsed ultrasound for bone healing, mostly based on the large pragmatic randomized controlled trial published in 2016.
A meta-analysis found that ultrasound therapy is effective in reducing pain, increasing ROM, and reducing WOMAC functional scores in patients with knee osteoarthritis. [7] There are three potential therapeutic mechanisms of ultrasound in physical therapy. The first is the increase in blood flow in the treated area.
Studies on localized prostate cancer showed that, after treatment, progression-free survival rates were high for low- and intermediate- risk patients with recurrent prostate cancer. [3] The InsighTec ExAblate 2000 was the first MRgFUS system to obtain FDA market approval, [ 4 ] US patent 5,247,935.
A low intensity (ISPTA < 5 W/cm2) pulsed ultrasound (LIPSA) approach can exploit the mechanical properties of neoplastic cells to target them for destruction. Ultrasound applied at a frequency of 0.5–0.67 MHz for >20 ms causes selective disruption of a panel of breast, colon, and leukemia cancer cell models in suspension without significantly damaging healthy immune or red blood cells.
The most successful treatment was that of lung cancer with 23.4% cell viability post-therapy. [1] [20] Qu et al. aimed to develop an "all-in-one" nanosensitizer platform triggered by SDT that combines various diagnostic and therapeutic effects to treat glioblastoma. [59] Apoptosis was successfully induced and mitophagy was inhibited in glioma ...
HIFU has CE approval for palliative care for bone metastasis. Experimentally, palliative care has been provided for cases of advanced pancreatic cancer. High-energy therapeutic ultrasound could increase higher-density anti-cancer drug load and nanomedicines to target tumor sites by 20x fold higher than traditional target cancer therapy. [38]
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