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Cupid is a method for simultaneous prediction of miRNA-target interactions and their mediated competing endogenous RNA (ceRNA) interactions. It is an integrative approach significantly improves on miRNA-target prediction accuracy as assessed by both mRNA and protein level measurements in breast cancer cell lines.
StarBase [2] is a database for decoding miRNA-mRNA, miRNA-lncRNA, [3] miRNA-sncRNA, miRNA-circRNA, [3] miRNA-pseudogene, protein-lncRNA, [4] protein-ncRNA, protein-mRNA interactions, and ceRNA networks [5] from CLIP-Seq (HITS-CLIP, PAR-CLIP, iCLIP, CLASH) and degradome sequencing data.
Cupid is a method for simultaneous prediction of miRNA-target interactions and their mediated competing endogenous RNA (ceRNA) interactions. It is an integrative approach significantly improves on miRNA-target prediction accuracy as assessed by both mRNA and protein level measurements in breast cancer cell lines.
CLIPSim-MC: CLIPSim-MC is a tool that uses CLIP-seq data to find miRNA/MRE pairings using a Monte-Carlo-based approach. [1]starBase database: a database for exploring miRNA-mRNA, miRNA-lncRNA, miRNA-sncRNA, miRNA-circRNA, miRNA-pseudogene, protein-lncRNA, protein-RNA interactions and ceRNA networks from HITS-CLIP (CLIP-Seq, PAR-CLIP, iCLIP, CLASH) data, and TargetScan [2], PicTar, RNA22 ...
miRTarBase [1] is a curated database of MicroRNA-Target Interactions.As a database, miRTarBase has accumulated more than fifty thousand miRNA-target interactions (MTIs), which are collected by manually surveying pertinent literature after data mining of the text systematically to filter research articles related to functional studies of miRNAs.
open-source database for molecular interactions Protein-protein and other molecular interactions String: an open source molecular interaction database to study interactions between proteins Protein-protein and other molecular interactions Human Protein Atlas: Human Protein Atlas: aims at mapping all the human proteins in cells, tissues and organs
The relation of miRNA and its target mRNA can be based on the simple negative regulation of a target mRNA, but it seems that a common scenario is the use of a "coherent feed-forward loop", "mutual negative feedback loop" (also termed double negative loop) and "positive feedback/feed-forward loop". Some miRNAs work as buffers of random gene ...
CLIP analysis of the RNA-binding protein Argonaute led to identification of microRNA targets [20] by decoding microRNA-mRNA and protein-RNA interaction maps in the mouse brain [11] [21] and subsequently in budding yeast (Saccharomyces cerevisiae), [22] Caenorhabditis elegans, [23] embryonic stem cells [24] and tissue culture cells. [25]