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At the time of its withdrawal, rofecoxib was the only coxib approved in the United States with clinical evidence of its superior gastrointestinal adverse effect profile over conventional NSAIDs. This was largely based on the VIGOR (Vioxx GI Outcomes Research) study, which compared the efficacy and adverse effect profiles of rofecoxib and naproxen .
Antidepressant discontinuation syndrome; Other names: Antidepressant withdrawal syndrome [1] Specialty: Psychiatry: Symptoms: Flu-like symptoms, trouble sleeping, anxiety, depression, dissociation, intrusive thoughts, nausea, poor balance, dizziness, sensory changes [2] Usual onset: Within 3 days [2] Duration: Few weeks to months [3] [4] Causes
Hepatotoxicity and Stevens–Johnson Syndrome [3] Chlorphentermine: 1969 Germany Cardiovascular Toxicity. [3] Cianidanol: 1985 France, Germany, Spain, Sweden Hemolytic Anemia. [3] Cinepazide: 1988 Spain Agranulocytosis. [12] [13] Cisapride (Propulsid) 2000 US Risk of fatal cardiac arrhythmias [2] Clioquinol: 1973 France, Germany, UK, US ...
Drug withdrawal, drug withdrawal syndrome, or substance withdrawal syndrome [1] is the group of symptoms that occur upon the abrupt discontinuation or decrease in the intake of pharmaceutical or recreational drugs. In order for the symptoms of withdrawal to occur, one must have first developed a form of drug dependence.
While some infections it causes — like impetigo, strep throat and scarlet fever — are treatable, it can also lead to cellulitis, necrotizing fasciitis and streptococcal toxic shock syndrome.
A statistically significant increase in the incidence of myocardial infarctions was observed in patients on rofecoxib. Further data, from the APPROVe trial, showed a statistically significant relative risk of cardiovascular events of 1.97 versus placebo [60] —which caused a worldwide withdrawal of rofecoxib in October 2004. [61]
USAID delivers billions of dollars in aid to dozens of countries. Shuttering it means wasted food, 'free-for-all' ISIS camps, and less HIV prevention.
She had pain and numbness in her hand, but thought it was due to carpel tunnel syndrome. At around 18, she saw a lump, but thought it was due to swelling.