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Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. COL1A1 encodes the major component of type I collagen , the fibrillar collagen found in most connective tissues , including cartilage .
Genetic defects of collagen genes; Type: Notes: Gene(s) Disorders: I: This is the most abundant collagen of the human body. It is present in scar tissue, the end product when tissue heals by repair. It is found in tendons, skin, artery walls, cornea, the endomysium surrounding muscle fibers, fibrocartilage, and the organic part of bones and ...
Type I collagen is the most abundant collagen of the human body, consisting of around 90% of the body's total collagen in vertebrates. Due to this, it is also the most abundant protein type found in all vertebrates. Type I forms large, eosinophilic fibers known as collagen fibers, which make up most of the rope-like dense connective tissue in ...
This (Gly-X-Y)n sequence is repeated 343 times in the type III collagen molecule. Proline or hydroxyproline is often found in the X- and Y-position giving the triple helix stability. In addition to being an integral structural component of many organs, type III collagen is also an important regulator of the diameter of type I and II collagen ...
Collagen alpha-3(VI) chain is a protein that in humans is encoded by the COL6A3 gene. [ 5 ] [ 6 ] [ 7 ] This protein is an alpha chain of type VI collagen that aids in microfibril formation. [ 8 ] As part of type VI collagen, this protein has been implicated in Bethlem myopathy, Ullrich congenital muscular dystrophy (UCMD), and other diseases ...
Collagen alpha-2(I) chain is a protein that in humans is encoded by the COL1A2 gene. [ 5 ] [ 6 ] This gene encodes one of the chains for type I collagen , the fibrillar collagen found in most connective tissues.