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Daflon is an oral micronized purified phlebotonic flavonoid fraction containing 90% diosmin and 10% hesperidin.It is manufactured by Laboratoires Servier and often used to treat or manage disorders of the blood vessels.
Diosmin is a dietary supplement used to aid treatment of hemorrhoids and venous diseases, i.e., chronic venous insufficiency including spider and varicose veins, leg swelling , stasis dermatitis and venous ulcers. [1] The mechanism of action of Diosmin and other phlebotonics is undefined, [1] and clinical evidence of benefit is limited. [1]
Venalex is made with a 9-1 ratio of diosmin and hesperidin. [2] Other ingredients. Hydroxypropol methylcellulose, magnesium stearate. References This page was last ...
Hesperidin is a flavanone glycoside found in citrus fruits. Its aglycone is hesperetin. Its name is derived from the word "hesperidium", for fruit produced by citrus trees. Hesperidin was first isolated in 1828 by French chemist M. Lebreton from the white inner layer of citrus peels (mesocarp, albedo). [2] [3]
Hesperidin 6-O-α-L-rhamnosyl-β-D-glucosidase is an enzyme that uses hesperidin and H 2 O to produce hesperetin and rutinose. [1]Upon digestion in the gastrointestinal tract, hesperetin – as for all flavonoids – is rapidly metabolized in intestinal and liver cells, releasing smaller metabolites into the blood and urine for excretion. [1]
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