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FDA has also formally approved combined pills for acne for specific brands. [15] Oral Contraceptive Pills are also effective in Hidradenitis Suppurativa. [16] There is also limited evidence for benefit of Combined oral contraceptive pill (OCP) as treatment for primary dysmenorrhoea.
EE/DRSP/LMF is the first and only birth control approved by the FDA for four indications: pregnancy prevention, symptomatic treatment of premenstrual dysphoric disorder, treatment of moderate acne, and raising folate levels to prevent neural tube defects for women who chose an oral contraceptive method. [8]
Such formulations contain low dosages of norethisterone (0.35 to 1 mg/day) [18] in combination with estrogen and are actually associated with improvement in acne symptoms. [43] [44] In accordance, they are in fact approved by the FDA Tooltip Food and Drug Administration for the treatment of acne in women in the United States.
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In 1989, the FDA approved Ortho Cyclen containing the first new progestin (norgestimate) approved in over 20 years in the United States. In 1992, Ortho introduced Ortho Tri-Cyclen in the United States, which in 1996 became the first oral contraceptive with an FDA-approved non-contraceptive indication (treatment of moderate acne).