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Nelson claims that relative to marijuana, products containing synthetic cannabinoids "are really quite different, and the effects are much more unpredictable. It's dangerous". [47] Since the term synthetic does not apply to the plant, but rather to the cannabinoid that the plant contains , the term synthetic cannabinoid is more appropriate. [48]
AB-FUBINACA (AMB-FUBINACA [2]) is a psychoactive drug that acts as a potent agonist for the cannabinoid receptors, with K i values of 0.9 nM at CB 1 and 23.2 nM at CB 2 and EC 50 values of 1.8 nM at CB 1 and 3.2 nM at CB 2.
[3] [4] In 2018, it was the third-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Administration. [ 5 ] The ( S )-enantiomer of ADB-FUBINACA is described in a 2009 Pfizer patent [ 6 ] and has been reported to be a potent agonist of the CB 1 receptor and the CB 2 receptor with EC 50 values of 1.2 nM and 3.5 ...
Aminoalkylindole is a class of synthetic cannabinoid compounds originally developed for cannabinoid receptor pharmacology studies but later emerged as drugs of abuse. They are often found in designer drugs known as synthetic cannabinoids (SCs) or "synthetic marijuana," and their use has been associated with various adverse health effects ...
Synthetic cannabinoids are known under a variety of names including K2, Spice, Black Mamba, Bombay Blue, Genie, Zohai, [38] Banana Cream Nuke, Krypton, and Lava Red. [39] They are often called "synthetic marijuana," "herbal incense," or "herbal smoking blends" and often labeled "not for human consumption."
The man who drove his car into a crowded sidewalk in Times Square on Thursday was high on synthetic marijuana (K2). Times Square driver was high on synthetic marijuana (K2) when he slammed into ...
Cannabinoid hyperemesis syndrome (CHS) is recurrent nausea, vomiting, and cramping abdominal pain that can occur due to prolonged, high-dose cannabis use. [4] [5]CHS is associated with frequent (weekly or more often), long-term (several months or longer) cannabis use; synthetic cannabinoids can also cause CHS.
Cannabinoids and their K i values [a]; Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x): JWH-007 [5]: Naphthoylindole: 9.5 ± 4.5