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phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID) phenylpropanolamine – controls urinary incontinence in dogs; phenytoin/pentobarbital – animal euthanasia product containing phenytoin and pentobarbital; pimobendan – phosphodiesterase 3 inhibitor used to manage heart failure in dogs; pirlimycin – antimicrobial; ponazuril ...
Phenylpropanolamine is readily- and well-absorbed with oral administration. [6] [7] [5] Immediate-release forms of the drug reached peak levels about 1.5 hours (range 1.0 to 2.3 hours) following administration. [4] [7] Conversely, extended-release forms of phenylpropanolamine reach peak levels after 3.0 to 4.5 hours. [4]
Pimobendan is indicated for the management of the signs of mild, moderate, or severe congestive heart failure in dogs due to clinical myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM); [1] [7] and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. [1]
The pharmacokinetics of phenylethanolamine, after intravenous administration to dogs, were studied by Shannon and co-workers, who found that the drug followed the "two-compartment model", with T 1/2 (α) ≃ 6.8 mins and T 1/2 (β) ≃ 34.2 mins; the "plasma half-life" of phenylethanolamine was therefore about 30 minutes. [15]
Chlorphenamine is often combined with phenylpropanolamine to form an allergy medication with both antihistamine and decongestant properties, though phenylpropanolamine is no longer available in the US after studies showed it increased the risk of stroke in young women. [7] Chlorphenamine remains available with no such risk.
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