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Hypericum perforatum, commonly known as St John's wort (sometimes perforate St John's wort or common St John's wort), is a flowering plant in the family Hypericaceae.It is a perennial plant that grows up to 1 metre (3 ft 3 in) tall, with many yellow flowers that have clearly visible black glands around their edges, long stamens (male reproductive organs), and three pistils (female reproductive ...
Edoxaban, sold under the brand name Lixiana among others, is an anticoagulant medication and a direct factor Xa inhibitor. [3] ... phenobarbital or St. John's Wort ...
They are effective in the arterial circulation where classical Vitamin K antagonist anticoagulants have minimal effect. [2] Antiplatelet drugs are widely used in primary and secondary prevention of thrombotic disease, especially myocardial infarction and ischemic stroke. [1]
Over-the-counter treatments for depression such as St. John’s wort. NSAIDs, naproxen and aspirin. Blood thinners and anticoagulants, like warfarin, due to risk of abnormal bleeding.
"Diarrhea, increased tendency for bleeding if used simultaneously with anticoagulants and inhibitors of thrombocytic aggregation due to modulation of the arachidonate cascade" [3] Psyllium seed Plantago spp Coumarin derivates Retards absorption of drug [3] St John's wort Tipton's weed, Klamath weed Hypericum perforatum
St. John's wort affects the clearance of numerous drugs, including cyclosporin, SSRI antidepressants, digoxin, indinavir, and phenprocoumon. [18] It may also interact with the anti-cancer drugs irinotecan and imatinib. [23] Salvia miltiorrhiza may enhance anticoagulation and bleeding among people taking warfarin. [19]
St. John's wort, sometimes recommended to help with mild to moderate depression, reduces the effectiveness of a given dose of warfarin; it induces the enzymes that break down warfarin in the body, causing a reduced anticoagulant effect. [75]
Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting anticoagulant to be taken by mouth, and a coumarin derivative. [2] It acts as a vitamin K antagonist and inhibits blood clotting (coagulation) by blocking synthesis of coagulation factors II, VII, IX and X.