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Sensory neuronopathy (also known as sensory ganglionopathy) is a type of peripheral neuropathy that results primarily in sensory symptoms (such as parasthesias, pain or ataxia) due to destruction of nerve cell bodies in the dorsal root ganglion. [1]
This disorder is characterized by the adult-onset triad consisting of the following symptoms: sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. MRIS often reveals white matter abnormalities and bilateral thalamus lesions. Other symptoms include generalized myopathy, epilepsy, and deafness. [1] [2]
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
Autoimmune autonomic ganglionopathy is a type of immune-mediated autonomic failure that is associated with antibodies against the ganglionic nicotinic acetylcholine receptor present in sympathetic, parasympathetic, and enteric ganglia. Typical symptoms include gastrointestinal dysmotility, orthostatic hypotension, and tonic pupils. [1]
The sensory root branches from the nasociliary nerve and travels through the ganglion forming part of the short ciliary nerves. These sensory axons supply the cornea, ciliary body and iris. The sympathetic root originates from the internal carotid plexus with cell bodies in the superior cervical ganglion. The axons pass through the ganglion and ...
Ocular neuropathic pain, also called corneal neuralgia, is a spectrum of disorders of ocular pain which are caused by damage or disease affecting the nerves.Ocular neuropathic pain is frequently associated with damaged or dysfunctional corneal nerves, [1] but the condition can also be caused by peripheral or centralized sensitization. [2]
[23] [3] It is classified as a sensory ganglionopathy due to involvement of these ganglia. [61] [b] In electrodiagnostic testing, it has characteristic non-length-dependent abnormalities of sensory action potentials that occur globally, rather than distally decreasing sensory nerve action potential amplitudes. [57]
The ophthalmic nerve (CN V 1) is a sensory nerve of the head.It is one of three divisions of the trigeminal nerve (CN V), a cranial nerve.It has three major branches which provide sensory innervation to the eye, and the skin of the upper face and anterior scalp, as well as other structures of the head.