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Cardiac markers are biomarkers measured to evaluate heart function. They can be useful in the early prediction or diagnosis of disease. [ 1 ] Although they are often discussed in the context of myocardial infarction , other conditions can lead to an elevation in cardiac marker level.
The diagnosis of myocardial infarction requires two out of three components (history, ECG, and enzymes). When damage to the heart occurs, levels of cardiac markers rise over time, which is why blood tests for them are taken over a 24-hour period.
A myocardial infarction (2) has occurred with blockage of a branch of the left coronary artery (1). A myocardial infarction, according to current consensus, is defined by elevated cardiac biomarkers with a rising or falling trend and at least one of the following: [82] Symptoms relating to ischemia
The CPK-MB test (creatine phosphokinase-MB), also known as CK-MB test, is a cardiac marker [3] used to assist diagnoses of an acute myocardial infarction, myocardial ischemia, or myocarditis. It measures the blood level of CK-MB (creatine kinase myocardial band), the bound combination of two variants (isoenzymes CKM and CKB ) of the enzyme ...
Cardiac troponins are a marker of all heart muscle damage, not just myocardial infarction, which is the most severe form of heart disorder. However, diagnostic criteria for raised troponin indicating myocardial infarction is currently set by the WHO at a threshold of 2 μg/L or higher.
H-FABP is a sensitive biomarker for myocardial infarction [12] [13] and can be detected in the blood within one to three hours of the pain.. The diagnostic potential of the biomarker H-FABP for heart injury was discovered in 1988 by Professor Jan Glatz (Maastricht, Netherlands). [14]