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Lipoblastoma is a type of rare, subcutaneous, benign, fatty tumor, [1] [2] found in infants, and children, more common in males with tendency of local recurrence. Local recurrence can happen in up to 80% of incompletely resected tumours.
In the research process of expanding the therapeutic uses of mesenchymal stem cells, they are grown in laboratories or grown using medication to stimulate new cell growth within the human body. In mesenchymal stem cell therapy, most of the cells are extracted from the adult patient's bone marrow [ 2 ] [ 3 ] Mesenchymal stem cells can be ...
These studies support prior epidemiologic data in humans showing a correlation between HMG I-C and mesenchymal tumors. [17] Cases have been reported where minor injuries are alleged to have triggered the growth of a lipoma, called a "post-traumatic lipoma". [18] However, the link between trauma and the development of lipomas is controversial. [19]
[3] [4] In addition, this cell line has a low expression of the Ki-67 proliferation marker, down regulation of claudin-3 and claudin-4, enrichment for markers associated with the epithelial-mesenchymal transition and the CD44+ CD24-/low phenotype associated with breast cancer stem cells and increased metastasis, [5] [6] [7] and is a mutant in ...
Lipoblasts (white arrow) and lipocytes (black arrow), in a case of lipoblastoma. Micrograph showing a lipoblast (left-bottom of image) in a liposarcoma. H&E stain.
The epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.
Molecular Cancer Research is a monthly peer reviewed academic journal published by the American Association for Cancer Research. Prior to September 2002 it was known as Cell Growth & Differentiation .
CD146 has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs, [10] and its expression may be linked to multipotency; mesenchymal stem cells with greater differentiation potential express higher levels of CD146 on the cell surface. [11]