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  2. Methyl-CpG-binding domain - Wikipedia

    en.wikipedia.org/wiki/Methyl-CpG-binding_domain

    The Methyl-CpG-binding domain (MBD) in molecular biology binds to DNA that contains one or more symmetrically methylated CpGs. [1] MBD has negligible non-specific affinity for unmethylated DNA. In vitro foot-printing with the chromosomal protein MeCP2 showed that the MBD could protect a 12 nucleotide region surrounding a methyl CpG pair. [1]

  3. Methyl-cpg binding domain protein 5 - Wikipedia

    en.wikipedia.org/wiki/Methyl-cpg_binding_domain...

    The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division ...

  4. Methyl-CpG-binding domain protein 2 - Wikipedia

    en.wikipedia.org/wiki/Methyl-CpG-binding_domain...

    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of ...

  5. Model-based definition - Wikipedia

    en.wikipedia.org/wiki/Model-based_definition

    Model-based definition (MBD), sometimes called digital product definition (DPD), is the practice of using 3D models (such as solid models, 3D PMI and associated metadata) within 3D CAD software to define (provide specifications for) individual components and product assemblies.

  6. MBD - Wikipedia

    en.wikipedia.org/wiki/MBD

    Megabaud (MBd), equal to one million baud, symbol rate in telecommunications Model-based definition , a method of using 3D CAD information to provide product specifications Model-based design , a mathematical and visual method of addressing problems associated with designing complex control, signal processing and communication systems

  7. MBD4 - Wikipedia

    en.wikipedia.org/wiki/MBD4

    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 (this gene) comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD).

  8. Metabolic bone disease - Wikipedia

    en.wikipedia.org/wiki/Metabolic_bone_disease

    Metabolic bone disease is an abnormality of bones caused by a broad spectrum of disorders. Most commonly these disorders are caused by deficiencies of minerals such as calcium, phosphorus, magnesium or vitamin D leading to dramatic clinical disorders that are commonly reversible once the underlying defect has been treated.