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Sodium thiosulfate is a classical antidote to cyanide poisoning, [10] For this purpose it is used after the medication sodium nitrite and typically only recommended for severe cases. [4] [6] It is given by injection into a vein. [4] In this use, sodium nitrite creates methemoglobinemia which removes cyanide from mitochondria. [6]
The relevant reaction is akin to the iodine reaction: thiosulfate reduces the hypochlorite (the active ingredient in bleach) and in so doing becomes oxidized to sulfate. The complete reaction is: 4 NaClO + Na 2 S 2 O 3 + 2 NaOH → 4 NaCl + 2 Na 2 SO 4 + H 2 O. Similarly, sodium thiosulfate reacts with bromine, removing the free bromine from ...
Thiosulfate: The evidence for sodium thiosulfate's use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the mitochondrial enzyme rhodanese (thiosulfate cyanide sulfurtransferase), which uses thiosulfate as ...
Thiosulfate (IUPAC-recommended spelling; sometimes thiosulphate in British English) is an oxyanion of sulfur with the chemical formula S 2 O 2− 3.Thiosulfate also refers to the compounds containing this anion, which are the salts of thiosulfuric acid, such as sodium thiosulfate Na 2 S 2 O 3 and ammonium thiosulfate (NH 4) 2 S 2 O 3.
Sodium nitrite/sodium thiosulfate, sold under the brand name Nithiodote, is a fixed-dose combination medication used as an antidote for cyanide poisoning. [1] It contains sodium thiosulfate and sodium nitrite. [1] It is given by intravenous infusion into a vein. [1] It was approved for medical use in the United States in January 2011. [2]
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This clock reaction uses sodium, potassium or ammonium persulfate to oxidize iodide ions to iodine. Sodium thiosulfate is used to reduce iodine back to iodide before the iodine can complex with the starch to form the characteristic blue-black color. Iodine is generated: 2 I − + S 2 O 2− 8 → I 2 + 2 SO 2− 4. And is then removed:
Thiosulfate–citrate–bile salts–sucrose agar, or TCBS agar, is a type of selective agar culture plate that is used in microbiology laboratories to isolate Vibrio species. [1] TCBS agar is highly selective for the isolation of V. cholerae and V. parahaemolyticus as well as other Vibrio species. Apart from TCBS agar, other rapid testing ...