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The activated protein C resistance (APCR) test is a coagulation test used in the evaluation and diagnosis of activated protein C (APC) resistance, a form of hypercoagulability. [ 1 ] [ 2 ] Hereditary APC resistance is usually caused by the factor V Leiden mutation, whereas acquired APC resistance has been linked to antiphospholipid antibodies ...
The protein C pathways are the specific chemical reactions that control the level of expression of APC and its activity in the body. [7]: 34 Protein C is pleiotropic, with two main classes of functions: anticoagulation and cytoprotection (its direct effect on cells). Which function protein C performs depends on whether or not APC remains bound ...
Protein C Anticoagulant Pathway: Thrombin escaping from a site of vascular injury binds to its receptor thrombomodulin (TM) on the intact cell surface. As a result, thrombin loses its procoagulant properties and instead becomes a potent activator of protein C. Activated protein C (APC) functions as a circulating anticoagulant, which ...
A blood test including platelets and a clotting screen should be performed prior to administration of anticoagulant regimens in pregnancy. [13] Subcutaneous tinzaparin may be given at doses of 175 units of antifactor Xa activity per kg, [13] based on prepregnancy or booking weight at approximately 16 weeks, and not the current weight. [13]
Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). [1] [2] [3] It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications. [2] [3] [4] It is a marker of thrombin generation and indicates hypercoagulability.
Repeated testing for protein C functional activity allows differentiation between transient and congenital deficiency of protein C. [5] [7] Initially, a protein C activity (functional) assay can be performed, and if the result is low, a protein C antigen assay can be considered to determine the deficiency subtype (Type I or Type II).