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Several approved drugs are being investigated as repurposed agents in the treatment of osteoarthritis such as liraglutide (anti-diabetic and anti-obesity drug: NCT02905864), Metformin (anti-diabetic drug: NCT04767841, NCT05034029), Zoledronic acid (anti-osteoporotic drug: NCT04303026), etc. [4] Paroxetine has been deemed to have DMOAD activity ...
Autologous conditioned serum, also known as Orthokine and Regenokine, is an experimental procedure in which a person's own blood is extracted, manipulated, and then reintroduced with claimed benefit in osteoarthritis. [1] There is limited evidence on safety and effectiveness as of 2017. [1] It is not included in medical guidelines as of 2017. [1]
Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population, as of 2015. [4] [12] It becomes more common as people age. [1] Among those over 60 years old, about 10% of males and 18% of females are affected. [2] Osteoarthritis is the cause of about 2% of years lived with disability. [12]
Non-operative treatment vs. hip replacement surgery for osteoarthritis of the hip (English) Painkillers vs. joint injections vs. knee replacement surgery for managing knee pain and activity level in osteoarthritis of the knee (English) Lifestyle and weight loss vs. medication for self-management of osteoarthritis of the knee (English and Spanish)
Osteoarthritis (OA) is caused by the wear and tear damage to the joint's cartilage.. The compelling pharmacological recommendations for the treatment of OA are oral NSAIDs, topical NSAIDs (for hands and knees), and I-A steroids.
Gene therapy for osteoarthritis is the application of gene therapy to treat osteoarthritis (OA). Unlike pharmacological treatments which are administered locally or systemically as a series of interventions, gene therapy aims to establish sustained therapeutic effect after a single, local injection.