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Between 1% and 15% of people globally are affected by kidney stones at some point. [14] [15] In 2015, they caused about 16,000 deaths worldwide. [16] Some of the oxalate in urine is produced by the body. Calcium and oxalate in the diet play a part but are not the only factors that affect the formation of calcium oxalate stones.
Struvite kidney stones are also known as triple phosphate stones (calcium magnesium ammonium phosphate), owing to the presence of carbonate apatite that precipitates to accompany struvite at high pH. [ 10 ] [ 11 ] [ 12 ] Struvite and carbonate apatite precipitate in alkaline urine , forming kidney stones.
Calcium phosphate stones account for approximately 15% of kidney stone disease. Calcium phosphate stones tend to grow in alkaline urine, especially when Proteus bacteria are present. It is the most common type in pregnant women. [6]
Many stone types can be detected by ultrasound; Factors contributing to stone formation (as in #Etiology) are often tested: Laboratory testing can give levels of relevant substances in blood or urine; Some stones can be directly recovered (at surgery, or when they leave the body spontaneously) and sent to a laboratory for analysis of content
Kidney stones can result from an underlying metabolic condition, such as distal renal tubular acidosis, [21] Dent's disease, [22] hyperparathyroidism, [23] primary hyperoxaluria, [24] or medullary sponge kidney. 3–20% of people who form kidney stones have medullary sponge kidney. [25] [26]
As a food additive, potassium citrate is used to regulate acidity, and is known as E number E332. Medicinally, it may be used to control kidney stones derived from uric acid or cystine . In 2020, it was the 297th most commonly prescribed medication in the United States, with more than 1 million prescriptions.