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  2. GM2 (ganglioside) - Wikipedia

    en.wikipedia.org/wiki/GM2_(ganglioside)

    In organic chemistry, GM2 is a type of ganglioside. G refers to ganglioside , the M is for monosialic (as in it has one sialic acid ), and 2 refers to the fact that it was the second monosialic ganglioside discovered.

  3. GM2 gangliosidoses - Wikipedia

    en.wikipedia.org/wiki/GM2_gangliosidoses

    The GM2 gangliosidoses are a group of three related genetic disorders that result from a deficiency of the enzyme beta-hexosaminidase. This enzyme catalyzes the biodegradation of fatty acid derivatives known as gangliosides. [1] The diseases are better known by their individual names: Tay–Sachs disease, AB variant, and Sandhoff disease.

  4. Ganglioside - Wikipedia

    en.wikipedia.org/wiki/Ganglioside

    A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. N-acetylneuraminic acid, NANA) linked on the sugar chain. NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of gangliosides anionic at pH 7, which distinguishes them from globosides .

  5. GM2A - Wikipedia

    en.wikipedia.org/wiki/GM2A

    The protein encoded by this gene is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.

  6. Sandhoff disease - Wikipedia

    en.wikipedia.org/wiki/Sandhoff_disease

    Sandhoff disease is a lysosomal genetic, lipid storage disorder caused by the inherited deficiency to create functional beta-hexosaminidases A and B. [1] [2] These catabolic enzymes are needed to degrade the neuronal membrane components, ganglioside GM2, its derivative GA2, the glycolipid globoside in visceral tissues, [1] and some oligosaccharides.

  7. Antiganglioside antibodies - Wikipedia

    en.wikipedia.org/wiki/Antiganglioside_antibodies

    Antibodies to ganglioside are found to be elevated in coeliac disease. [16] Recent studies show that gliadin can cross-link to gangliosides in a transglutaminase independent manner, indicating that gliadin specific T-cell could present these antigens to the immune system.

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  9. Gangliosidosis - Wikipedia

    en.wikipedia.org/wiki/Gangliosidosis

    This article about an endocrine, nutritional, or metabolic disease is a stub. You can help Wikipedia by expanding it.