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Hemolytic anemia or haemolytic anaemia is a form of anemia due to ... Examination of a peripheral blood smear and some other laboratory studies can contribute to the ...
Unconjugated hyperbilirubinemia above 15% is present. The differential diagnoses are rifampicin or probenecid use, inherited disorders like Gilbert's syndrome and other hemolytic disorders. On peripheral smears, fragmented RBCs, burr cells, helmet cells and triangle cells are seen. [3] [4]
Schistocytes on the peripheral blood smear is a characteristic feature of microangiopathic hemolytic anemia (MAHA). [5] The causes of MAHA can be disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, HELLP syndrome, malfunctioning cardiac valves etc. In most of the conditions, schistocytes are ...
Spherocytosis can be diagnosed in Peripheral blood film by seeing spherical red blood cells rather than biconcave. Because spherical red blood cells are more prone to lysis in water (because they lack some proteins in their cytoskeleton) there will be increased osmotic fragility on acidified glycerol lysis test.
Disorders such as iron deficiency anemia, sickle cell anemia, megaloblastic anemia and microangiopathic hemolytic anemia result in characteristic abnormalities on the blood film. [2] The proportions of different types of white blood cells can be determined from the blood smear.
Drug-independent autoantibodies are found in Drug-induced autoimmune hemolytic anemia because of beta-lactamase inhibitors and platinum-based chemotherapeutics. These autoantibodies can sometimes bind and react to red blood cells even in the absence of whatever drug triggered the anemia .
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