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Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
The plasma half-life or half life of elimination is the time required to eliminate 50% of the absorbed dose of a drug from an organism. Or put another way, the time that it takes for the plasma concentration to fall by half from its maximum levels.
There is an important relationship between clearance, elimination half-life and distribution volume. The elimination rate constant of a drug K e l {\displaystyle K_{el}} is equivalent to total clearance divided by the distribution volume
Elimination half-life: The time required for the concentration of the drug to reach half of its original value. 12 h Elimination rate constant: The rate at which a drug is removed from the body.
A biological half-life or elimination half-life is the time it takes for a substance (drug, radioactive nuclide, or other) to lose one-half of its pharmacologic, physiologic, or radiological activity.
However, its duration remains short, with an elimination half-life of 1.6 hours and a mean residence time of 3.7 hours. [33] [34] [35] Oral testosterone undecanoate is provided as 40 mg oil-filled capsules and requires administration 2 to 4 times per day (i.e., 80 to 160 mg/day) for substitution in men.
The elimination rate constant K or K e is a value used in pharmacokinetics to describe the rate at which a drug is removed ... t 1/2 is the half-life time of the drug
[17] [194] The apparent elimination half-life of estradiol with transdermal estradiol gel is 36 hours. [194] Once daily application of 1.25 g topical gel containing 0.75 mg estradiol (brand name EstroGel) for 2 weeks was found to produce mean peak estradiol and estrone levels of 46.4 pg/mL and 64.2 pg/mL, respectively. [194]