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However, the Mayo Clinic has reported significant success treating early bile duct cancer with liver transplantation using a protocolized approach and strict selection criteria. [71] Adjuvant therapy followed by liver transplantation may have a role in treatment of certain unresectable cases. [72]
The following are the most common treatments of elevated alkaline phosphatase. [23] Treatment of the underlying condition. Once doctors identify the cause of elevated ALP and diagnose a treatment, the levels of alkaline phosphatase fluctuates back to normal; Removal of medication. Drugs can be associated with increased levels of alkaline ...
However, if signs and symptoms are present they include non-specific abdominal pain, yellowing of skin, and higher than normal gamma glutamyl transferase and alkaline phosphatase laboratory values. [7] They are, in most cases, located in the right hepatic lobe and are frequently seen as a single lesion. [7]
Alkaline phosphatase (ALP) is an enzyme in the cells lining the biliary ducts of the liver. It can also be found on the mucosal epithelium of the small intestine, proximal convoluted tubule of the kidneys, bone, liver, and placenta. It plays an important role in lipid transposition in small intestines and calcification of bones. 50% of all the ...
Polycystic liver disease (PLD) usually describes the presence of multiple cysts scattered throughout normal liver tissue. [1] PLD is commonly seen in association with autosomal-dominant polycystic kidney disease, with a prevalence of 1 in 400 to 1000, and accounts for 8–10% of all cases of end-stage renal disease. [2]
Diagnosis requires elevated serum alkaline phosphatase persisting for at least 6 months and the presence of bile duct strictures on cholangiogram. [39] [40] Unlike primary biliary cholangitis, PSC lacks a diagnostic autoantibody or reliable biomarker of disease progression.
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