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Glucose binds to hexokinase in the active site at the beginning of glycolysis. In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. [1]
As glucokinase is a monomeric enzyme with only a single binding site [16] for glucose the cooperativity cannot be explained in terms of classical models of equilibrium cooperativity, but requires a kinetic explanation, such as a slow-transition model [17] or a "memonical" model that invokes enzyme memory. [18]
Binding of glucose to one site provokes a conformational change associated with transport, and releases glucose to the other side of the membrane. The inner and outer glucose-binding sites are, it seems, located in transmembrane segments 9, 10, 11; [ 8 ] also, the DLS motif located in the seventh transmembrane segment could be involved in the ...
Despite there being two binding sites for glucose, it is proposed that glucose binding at one site induces a conformational change which prevents a second glucose from binding the other site. [13] Meanwhile, the first 12 amino acids of the highly hydrophobic N -terminal serve to bind the enzyme to the mitochondria , while the first 18 amino ...
Hexokinase IV is monomeric, about 50kDa, displays positive cooperativity with glucose, and is not allosterically inhibited by its product, glucose-6-phosphate. [ 4 ] Hexokinase IV is present in the liver , pancreas , hypothalamus , small intestine , and perhaps certain other neuroendocrine cells, and plays an important regulatory role in ...
80201 216019 Ensembl ENSG00000156510 ENSMUSG00000020080 UniProt Q2TB90 Q91W97 RefSeq (mRNA) NM_025130 NM_145419 RefSeq (protein) NP_079406 NP_663394 Location (UCSC) Chr 10: 69.22 – 69.27 Mb Chr 10: 62.22 – 62.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hexokinase domain containing 1 (HKDC1) is an enzyme which in humans is encoded by the HKDC1 gene on chromosome 10. It is a ...