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Without treatment, the sleep deprivation and lack of oxygen caused by sleep apnea increases health risks such as cardiovascular disease, aortic disease (e.g. aortic aneurysm), [165] high blood pressure, [166] [167] stroke, [168] diabetes, clinical depression, [169] weight gain, obesity, [66] and even death.
Alzheimer's disease and severe obstructive sleep apnea are connected [39] because there is an increase in the protein beta-amyloid as well as white-matter damage. These are the main indicators of Alzheimer's, which in this case comes from the lack of proper rest or poorer sleep efficiency resulting in neurodegeneration.
The loop gain is calculated by imagining the feedback loop is broken at some point, and calculating the net gain if a signal is applied. In the diagram shown, the loop gain is the product of the gains of the amplifier and the feedback network, −Aβ. The minus sign is because the feedback signal is subtracted from the input.
The respiratory disturbance index (RDI)—or respiratory distress Index—is a formula used in reporting polysomnography (sleep study) findings. Like the apnea-hypopnea index (AHI), it reports on respiratory distress events during sleep, but unlike the AHI, it also includes respiratory-effort related arousals (RERAs). [1]
Sleep-related breathing disorders, such as sleep apnea [1] [2] Sleep-related seizure disorders [1] Sleep-related movement disorders, such as periodic limb movement disorder, which is repeated muscle twitching of the feet, legs, or arms during sleep. [2] [1] Sleep studies may be used to diagnose or rule out restless legs syndrome (RLS). However ...
Causes may include heart failure, kidney failure, narcotic poisoning, intracranial pressure, and hypoperfusion of the brain (particularly of the respiratory center). The pathophysiology of Cheyne–Stokes breathing can be summarized as apnea leading to increased CO 2 which causes excessive compensatory hyperventilation, in turn causing decreased CO 2 which causes apnea, restarting the cycle.