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Rituximab (Anti-CD20 antibody) has been used to treat pemphigus erythematosus. Immunosuppressant medication is the most common treatment for pemphigus erythematosus. [ 1 ] Corticosteroids such as oral prednisone pills are an established long-term therapy for pemphigus.
Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus.Pemphigus was derived from the Greek word pemphix, meaning blister. [1] It is classified as a type II hypersensitivity reaction in which antibodies are formed against desmosomes, components of the skin that function to keep certain layers of skin bound to each other.
Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
Roche (RHHBY) announces positive data on rheumatic diseases drug, Rituxan, for pemphigus vulgaris.
[17] [18] Currently rituximab is considered a first-line treatment for some pemphigus patients according to Delphi consensus recommendations [19] All of these drugs may cause severe side effects, so patients should be closely monitored by doctors. Once the outbreaks are under control, dosage is often reduced, to lessen side effects.
He has more than 592 publications to his credit, in national and international Textbooks and Journals. In 2011, he was credited as first in India to report efficacy and safety of Rituximab for treatment of Pemphigus. [11] He is co-author of Textbook of Surgical Management of Vitiligo published by Blackwell [12] [13]
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