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A tablet press in operation An old rotary tablet press. A tablet press is a mechanical device that compresses powder into tablets of uniform size and weight. A tablet press can be used to manufacture tablets of a wide variety of materials, including pharmaceuticals, nutraceuticals, cleaning products, industrial pellets and cosmetics.
ACG Engineering provides Machines for the oral Solid dosage part of the pharma industry, right from granulation equipment, capsule filling machines, tablet press, tablet coaters, tablet tooling, and packaging machines like blister packing and Cartoning machines. [10] ACG has completed more than 20,000 machine installations. [11]
The compression is done either by a single-punch machine (also called stamping press, achieves an output of approximately 200 tablets per minute, making it ideal for manufacturing small batches of tablets) or by a multi-station machine (rotary press). The tablet press is a high-speed mechanical device.
Tablet formulations are designed and tested using a laboratory machine called a Tablet Compaction Simulator or Powder Compaction Simulator. This is a computer controlled device that can measure the punch positions, punch pressures, friction forces, die wall pressures, and sometimes the tablet internal temperature during the compaction event.
The documentation of activities by pharmaceutical manufacturers is a license-to-operate endeavor, supporting both the quality of the product produced and satisfaction of regulators who oversee manufacturing operations and determine whether a manufacturing process may continue or must be terminated and remediated.
For compression testing, the analyst generally aligns the tablet in a repeatable way, [2] and the tablet is squeezed between a fixed and a moving jaw. The first machines continually applied force with a spring and screw thread until the tablet started to break. [3] When the tablet fractured, the hardness was read with a sliding scale. [3]
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The compression rolls do the heavy pressing (yes, they actually rotate) and the punches actually travel directly on the rolls during this compression step. A typical force might be 10 kNewtons on the first set and 30kN (equivalent to about 3000kg force) on the second set. The photo on tablet is a good comparison.