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The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABA A and GABA B .
GABA transporters (gamma-aminobutyric acid transporters) are a family of neurotransmitter / sodium symporters, belonging to the solute carrier 6 family. [1] [2] They are found in various regions of the brain in different cell types, such as neurons and astrocytes.
Neurotransmitters are essential to the function of complex neural systems. The exact number of unique neurotransmitters in humans is unknown, but more than 100 have been identified. [3] Common neurotransmitters include glutamate, GABA, acetylcholine, glycine, dopamine and norepinephrine.
Otherwise known as gamma-aminobutyric acid, GABA is an amino acid produced in the brain. Here, experts explain GABA uses and side effects.
The only difference noted so far is a slight elevation of brain Taurine levels. [2] This was an unexpected finding, but is in agreement with the notion that GAT2 permits efflux of GABA and taurine from the brain to circulating blood through the blood brain barrier. [3]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts on the repertoire of GABA A receptors, the ligand-gated chloride channels. It is assembled from a diverse subunit pool, including assemblies from a family of 19 subunits (α1-α6, β1-β3, γ1-γ3, δ, ∈, θ, π and ρ1-ρ3).
Jaba', Haifa, a village near Mount Carmel, Israel also known as Gaba; Jab'a, a village in the West Bank, southwest of Jerusalem, also known as Gaba; Gaba, ancient city in what is now Tel Shush; Gaba, a Persian city located in what is now known as Isfahan; Gaba, a suburb of Makindye, Kampala, Uganda, on the shores of Lake Victoria
In the mammalian brain, two predominant, differentially expressed isoforms of the GABA B1 are transcribed from the Gabbr1 gene, GABA B(1a) and GABA B(1b), which are conserved in different species including humans. [12] This might potentially offer more complexity in terms of the function due to different composition of the receptor. [12]