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To probe insular neural circuits, Gogolla and her lab use in vivo two-photon calcium imaging to record neural activity while mice are processing emotionally relevant stimuli, and they further use innovative behavioral assays, optogenetic techniques, and machine learning algorithms to link neural activity to behavior, manipulate neural circuits ...
For her graduate studies at Caltech, Choi joined the lab of David Anderson, who at the time was just switching his research focus from neural crest cells to neural circuits underlying innate behaviors. [4] Early into her graduate career, Choi explored the fate specification and differentiation of cells of the central nervous system in development.
Much research has been done into the use of a rat model to show how Borna virus infection, [17] [18] exposure to valproic acid in utero, [19] and maternal immune activation [20] may cause autism. Another goal of the use of rodent models to study autism is to identify the mechanism by which autism develops in humans. [ 1 ]
The underconnectivity theory of autism posits that autistic people tend to have fewer high-level neural connections and less global synchronization, along with an excess of low-level processes. [31] Functional connectivity studies have found both hypo- and hyperconnectivity in brains of autistic people. [ 32 ]
The most current model illustrating MECP2 is known as the transcriptional activator model. Another potential molecular convergence involves the early growth response gene-2 (EGR2). [ 60 ] EGR2 is the only gene in the EGR family that is restricted to the central nervous system and is involved in cerebral development and synaptic plasticity . [ 60 ]
The IACC Strategic Plan was designed to detail research opportunities centered on the six most pressing questions facing those affected by autism and links them to specific research efforts. In 2009, the plan was finalized and submitted to the Secretary of the Department of Health and Human Services; a seventh question related to infrastructure ...
The behavioral development model of motor activity has produced a number of techniques, including operant-based biofeedback to facilitate development with success. Some of the stimulation methods such as operant-based biofeedback have been applied as treatment to children with cerebral palsy and even spinal injury successfully.
Research in Autism Spectrum Disorders is a peer-reviewed medical journal published monthly by Elsevier. It covers applied topics pertaining to autism spectrum disorders. Since the spring of 2023, the editor-in-chief is David Beversdorf (University of Missouri). According to the Journal Citation Reports, in 2012 the journal had an impact factor ...