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Chk1/2 phosphorylate cdc25 which, in addition to being inhibited, is also sequestered in the cytoplasm by the 14-3-3 proteins. 14-3-3 are upregulated by p53, which, as previously mentioned, is activated by Chk1 and ATM/ATR. p53 also transactivates p21, and both p21 and the 14-3-3 in turn inhibit cyclin B-cdc2 complexes through the ...
The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes until each chromosome is properly attached to the ...
Martha Bradley (fl. 1740s – 1755) was a British cookery book writer. Little is known about her life, except that she published the cookery book The British Housewife (pictured) in 1756 and worked as a cook for more than 30 years in the fashionable spa town of Bath, Somerset.
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Iraq Army soldier mans a checkpoint during Operation Red Light II US Army tanks and Soviet tanks at Checkpoint Charlie, 1961. Though practices and enforcement vary, checkpoints have been used in: Airports and other transportation hubs across the world, including those managed by the TSA in the United States. Post World War II checkpoints in Germany
A scanning electron microscope image of a single neutrophil (yellow/right), engulfing anthrax bacteria (orange/left) – scale bar is 5 μm (false color). The immune system is a network of biological systems that protects an organism from diseases.