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Calcium and Vitamin D3 are often combined, with claims for adult bone health (This label predates current U.S. Food and Drug Administration regulations on health claims. [ 92 ] ) Characteristics of osteomalacia are softening of the bones, leading to bending of the spine, bone fragility, and increased risk for fractures. [ 1 ]
Calcium forms complexes with a number of pharmaceutical drugs, reducing their bioavailability; among them are tetracyclines, quinolone antibiotics, levothyroxine, and bisphosphonates, as well as iron, magnesium and zinc supplements. Vitamin D in usual doses has no relevant interactions. [2]
Vitamin K2 may have a protective effect on bone mineral density and reduced risk of hip, vertebral and non-vertebral fractures. [11] These effects appear to be accentuated when combined with vitamin D and in the setting of osteoporosis. [1] Research suggests that vitamin K 2 (Menaquinone 7, MK-7]) may reduce the rate and severity of night time ...
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
Magnesium is absorbed orally at about 30% bioavailability from any water soluble salt, such as magnesium chloride or magnesium citrate. The citrate is the least expensive soluble (high bioavailability) oral magnesium salt available in supplements, with 100 mg and 200 mg magnesium typically contained per capsule, tablet or 50 mg/mL in solution. [26]
This is important for maintaining calcium levels and promoting bone health and development. [4] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D deficiency. One gram is 40 000 000 (40 × 10 6) IU, equivalently 1 IU is 0.025 μg, or 25 ng.