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Traditionally, the most effective treatment for hot flashes has been estrogen supplementation – often referred to as hormone replacement therapy. Unfortunately, estrogen isn’t recommended for ...
Research on hot flashes is mostly focused on treatment options. The exact cause and pathogenesis, or causes, of vasomotor symptoms (VMS)—the clinical name for hot flashes—has not yet been fully studied. [11] [12] Hot flashes are associated with declining levels of estrogen (estrogen withdrawal) and other hormonal changes. [13]
After 12 weeks, women taking elinzanetant were reporting having about 10 fewer hot flashes each day on average compared with an average change of about seven hot flashes each day in the placebo group.
A Phase 3 trial showed that it improved hot flashes in slightly less than half of those who took it: 48% of women on a higher dose and 36% of those on a lower dose reported being much, or ...
Elinzanetant (developmental code names BAY-3427080 GSK-1144814, NT-814) is an orally active small-molecule neurokinin/tachykinin NK 1 receptor and NK 3 receptor antagonist which is under development by Bayer, GlaxoSmithKline, and NeRRe Therapeutics for the treatment of hot flashes and "sex hormone disorders".
Approved uses of HRT in the United States include short-term treatment of menopausal symptoms such as hot flashes and vaginal atrophy, and prevention of osteoporosis. [13] The American College of Obstetrics and Gynecology (ACOG) approves of HRT for symptomatic relief of menopausal symptoms, [ 14 ] and advocates its use beyond the age of 65 in ...
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