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Women conversely are at higher risk for developing autoimmune disease, but are more protected from infectious disease than men. Women have a greater number of circulating antibodies than do men, [46] which has implications for their development of autoimmune disease, as well as their increased resistance to infectious disease.
Adverse reactions from the use of prednisolone include: [40] [7] Increased appetite, weight gain, nausea, and malaise; Increased risk of infection; Cardiovascular events; Dermatological effects including reddening of the face, bruising/skin discoloration, impaired wound healing, skin atrophy, skin rash, edema, and abnormal hair growth
The dose and mode of administration is determined by platelet count and whether there is active bleeding: in urgent situations, infusions of dexamethasone or methylprednisolone may be used, while oral prednisone or prednisolone may suffice in less severe cases. Once the platelet count has improved, the dose of steroid is gradually reduced while ...
Excessive glucocorticoid levels resulting from administration as a drug or hyperadrenocorticism have effects on many systems. Some examples include inhibition of bone formation, suppression of calcium absorption (both of which can lead to osteoporosis), delayed wound healing, muscle weakness, and increased risk of infection. These observations ...
Prednisone was patented in 1954 and approved for medical use in the United States in 1955. [3] [8] It is on the World Health Organization's List of Essential Medicines. [9] It is available as a generic medication. [3] In 2022, it was the 30th most commonly prescribed medication in the United States, with more than 18 million prescriptions. [10 ...
This is also called 'red skin syndrome' or 'topical steroid withdrawal' (TSW). After the withdrawal period is over the atopic dermatitis can cease or is less severe than it was before. [40] In children the short term use of steroids by mouth increases the risk of vomiting, behavioral changes, and sleeping problems. [41]
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In general, use a potent preparation short term and weaker preparation for maintenance between flare-ups. While there is no proven best benefit-to-risk ratio, [11] if prolonged use of a topical steroid on a skin surface is required, a pulse therapy should be undertaken.