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Postorgasmic illness syndrome (POIS) is a syndrome in which human males have chronic physical and cognitive symptoms following ejaculation. [1] The symptoms usually onset within seconds, minutes, or hours, and last for up to a week. [1] The cause and prevalence are unknown; [2] it is considered a rare disease. [3]
As of 2016, the International Society for the Study of the Aging Male defines late-onset hypogonadism as a series of symptoms in older adults related to testosterone deficiency that combines features of both primary and secondary hypogonadism; the European Male Aging Study (a prospective study of ~3000 men) [10] defined the condition by the presence of at least three sexual symptoms (e.g ...
PMDD follows a predictable, cyclic pattern. Symptoms begin in the late luteal phase of the menstrual cycle (after ovulation) and end or are markedly reduced shortly after menstruation begins. [13] On average, the symptoms last six days but can start up to two weeks before menses, meaning symptoms can be felt for up to three weeks out of a cycle.
Ovulation occurs ~35 hours after the beginning of the LH surge or ~10 hours following the LH surge. Several days after ovulation, the increasing amount of estrogen produced by the corpus luteum may cause one or two days of fertile cervical mucus, lower basal body temperatures, or both. This is known as a "secondary estrogen surge".
Physical arousal caused by PGAD can be very intense and persist for extended periods, days, weeks or years at a time. [3] [4] Symptoms may include pressure, pain, vibrating, pleasure, irritation, clitoral or penile [5] tingling, throbbing, vaginal congestion, vaginal contractions, penile spasms, arousal, clitoral or penile erections, and prolonged spontaneous orgasms. [3]
Although the refractory period varies widely among individuals, ranging from minutes to days, [4] [5] [6] most men cannot achieve or maintain an erection during this time, and many perceive a psychological feeling of satisfaction and are temporarily uninterested in further sexual activity; the penis may be hypersensitive, and further sexual stimulation may feel painful during this time frame.
Headache, nausea, vomiting, diarrhea, and fatigue may also accompany the pain. Pain may begin gradually, with the first several years of menses, and then intensified as menstruation becomes regular. Patients who also have secondary amenorrhea report symptoms beginning after age 20 and lasting 5–7 days with progressive worsening of pain over time.
The condition and its effects on both men and women is the topic for example of the novel set in Nigeria entitled, The Secret Lives of Baba Segin's Wives. A lot of research has pointed to the relationship between infertility and emasculation. [85] [86] [87] This association has led to infertility being less studied and diagnosed in men over ...