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Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Eplerenone is an antimineralocorticoid, or an antagonist of the mineralocorticoid receptor (MR). [21] Eplerenone is also known chemically as 9,11α-epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone and "was derived from spironolactone by the introduction of a 9α,11α-epoxy bridge and by substitution of the 17α-thoacetyl ...
Potassium-sparing diuretics act to prevent sodium reabsorption in the collecting tubule by either binding ENaCs (amiloride, triamterene) or by inhibiting aldosterone receptors (spironolactone, eplerenone). This prevents excessive excretion of K + in urine and decreased retention of water, preventing hypokalemia. [10]
The Westbay MP system is a modular instrumentation system for multilevel groundwater monitoring acquired by Nova Metrix in 2015, the MP system consists of two parts: (1) the casing system and (2) portable probes and tools that provide a compatible data acquisition system. The Westbay casing system is designed to allow the monitoring of multiple ...
Water quality monitoring is of little use without a clear and unambiguous definition of the reasons for the monitoring and the objectives that it will satisfy. Almost all monitoring (except perhaps remote sensing ) is in some part invasive of the environment under study and extensive and poorly planned monitoring carries a risk of damage to the ...
CEM systems can also measure air flow, flue gas opacity and moisture. A monitoring system that measures particulate matter is referred to as a PEMS. In the U.S., the EPA requires a data acquisition and handling system to collect and report the data. Measurements of concentration can be converted to mass/hour by including flow rate measurements.