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The most serious signs and symptoms associated with Marfan syndrome involve the cardiovascular system: undue fatigue, shortness of breath, heart palpitations, racing heartbeats, or chest pain radiating to the back, shoulder, or arm. Cold arms, hands, and feet can also be linked to MFS because of inadequate circulation.
Heritable connective tissue diseases are rare, each disorder estimated at one to ten per 100,000, of which Marfan syndrome is the most common. It is carried by the FBN1 gene on chromosome 15, which encodes the connective protein fibrillin-1, [ 12 ] [ 13 ] inherited as a dominant trait.
Rheumatic fever (RF), Marfan's syndrome and the Ehlers–Danlos syndromes are other typical causes. [6] Mitral valve stenosis (MVS) can sometimes be a cause of mitral regurgitation (MR) in the sense that a stenotic valve ( calcified and with restricted range of movement) allows backflow (regurgitation) if it is too stiff and misshapen to close ...
A number of genetic conditions are associated with heart defects, including Down syndrome, Turner syndrome, and Marfan syndrome. [3] Congenital heart defects are divided into two main groups: cyanotic heart defects and non-cyanotic heart defects, depending on whether the child has the potential to turn bluish in color. [3]
Symptoms: severe chest or back pain, vomiting, sweating, lightheadedness [1] [2] Complications: Stroke, mesenteric ischemia, myocardial ischemia, aortic rupture [2] Usual onset: Sudden [1] [2] Risk factors: High blood pressure, Marfan syndrome, Loeys-Dietz Syndrome, Turner syndrome, bicuspid aortic valve, previous heart surgery, major trauma ...
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Marfan syndrome Lincoln sign is the medical sign consisting of excessive popliteal artery pulsation due to hemodynamic effects of aortic regurgitation . [ 1 ] This sign is associated with Marfan syndrome , in which aortic root dilation and aortic incompetence are common features.
Ritter's official cause of death was an undetected aortic dissection, when the body's main artery, aka the aorta, tears. However, doctors initially thought the actor was experiencing a heart attack.
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