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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. [ 1 ]
Advanced Placement (AP) Biology (also known as AP Bio) is an Advanced Placement biology course and exam offered by the College Board in the United States. For the 2012–2013 school year, the College Board unveiled a new curriculum with a greater focus on "scientific practices". [1]
One 2014 study of math and science AP courses showed that participation rates were 52.7% for AP Chemistry, 53.6% for AP Physics, 57.7% for AP Biology, and 77.4% for AP Calculus. [67] A 2017 study found similar participation rates (49.5% for AP Chemistry, 52.3% for AP Physics, 54.5% for Biology, and 68.9% for Calculus).
Miguel Lee as Eduardo, Victor's childhood best friend who transfers into the AP Biology class (seasons 2–4) Jacob Timothy Manown as Caleb, an AP Bio student who is also in the drama club. He writes in his free time and is a fan of Principal Durbin's old ska band. (seasons 2–4) Jaime Moyer as Joyce (seasons 2–4)
The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus . Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac -LYASSNPApY- NH2 peptide in the juxtamembrane region of the insulin receptor.
The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. [1] It has been found to be conserved between mammalian species, [2] as well as yeast [1] [3] and worm organisms. The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the
Protoplasm (/ ˈ p r oʊ t ə ˌ p l æ z əm /; [1] [2] pl. protoplasms) [3] is the part of a cell that is surrounded by a plasma membrane.It is a mixture of small molecules such as ions, monosaccharides, amino acids, and macromolecules such as proteins, polysaccharides, lipids, etc.
An estimated 1/10 to 1/2 of proteins are phosphorylated in some cellular state. 30–65% of proteins in humans and ~50% of proteins in yeast may be phosphorylated. [15] [2] An estimated 230,000, 156,000, and 40,000 phosphorylation sites exist in human, mouse, and yeast, respectively. [2]