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A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells. They are predominantly ...
1.1 cGMP phosphodiesterase inhibitors. 2 See also. 3 Sources. ... Printable version; In other projects ... This page was last edited on 9 February 2024, ...
Printable version; In other projects ... PDE4 inhibitors (23 P) PDE5 inhibitors ... Pages in category "Phosphodiesterase inhibitors" The following 40 pages are in ...
The potential for selective phosphodiesterase inhibitors to be used as therapeutic agents was predicted in the 1970s by Weiss and coworkers. [5] This prediction has now come to pass in a variety of fields (e.g. sildenafil as a PDE5 inhibitor and Rolipram as a PDE4 inhibitor).
It inhibits PDE4 to the greatest extent, but also shows significant inhibition of other PDE subtypes, and so acts as a selective PDE4 inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Piclamilast, a more potent inhibitor than rolipram. [25] Luteolin, supplement extracted from peanuts that also possesses IGF-1 ...
Print/export Download as PDF; Printable version; In other projects ... Pages in category "PDE4 inhibitors" The following 23 pages are in this category, out of 23 ...
Print/export Download as PDF; Printable version; In other projects Wikidata item; Appearance. ... PDE4 inhibitor This page was last edited on 2 July 2022 ...
Piclamilast (RP 73401), is a selective PDE4 inhibitor. [1] It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma.