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Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [ 6 ] [ 7 ] [ 9 ] Its elimination half-life after multiple doses is 21 days.
The IUPAC name of haloperidol decanoate is [4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] decanoate. Topical formulations of haloperidol should not be used as treatment for nausea because research does not indicate this therapy is more effective than alternatives. [39]
Haloperidol decanoate, an antipsychotic ester. An antipsychotic ester is an ester of an antipsychotic . [ 1 ] They are used clinically as prodrugs to increase fat solubility and thereby prolong duration when antipsychotics are used as depot injectables .
Typical antipsychotics block the dopamine 2 receptor (D2) receptor, causing a tranquilizing effect. [5] It is thought that 60–80% of D2 receptors need to be occupied for antipsychotic effect. [5] For reference, the typical antipsychotic haloperidol tends to block about 80% of D2 receptors at doses ranging from 2 to 5 mg per day. [5]
Antipsychotics by class Generic name Brand names Chemical class ATC code Typical antipsychotics; Acepromazine: Atravet, Acezine: phenothiazine: N05AA04
5.2–5.8 [7] Haloperidol decanoate: Haldol Decanoate: Typical: Sesame oil: 20–400 mg/2–4 weeks: 3–9 days: 18–21 days: 7.2–7.9 [8] [9] Olanzapine pamoate ...
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