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In immunology, clonal selection theory explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. The concept was introduced by Australian doctor Frank Macfarlane Burnet in 1957, in an attempt to explain the great diversity of antibodies formed during initiation of the immune response .
Clonal Selection Pseudo code on AISWeb; CLONALG in Matlab developed by Leandro de Castro and Fernando Von Zuben; Optimization Algorithm Toolkit in Java developed by Jason Brownlee which includes the following clonal selection algorithms: Adaptive Clonal Selection (ACS), Optimization Immune Algorithm (opt-IMMALG), Optimization Immune Algorithm (opt-IA), Clonal Selection Algorithm (CLONALG ...
De Castro & Von Zuben's and Nicosia & Cutello's work (on clonal selection) became notable in 2002. The first book on Artificial Immune Systems was edited by Dasgupta in 1999. Currently, new ideas along AIS lines, such as danger theory and algorithms inspired by the innate immune system, are also being explored. Although some believe that these ...
The theory is now sometimes known as Burnet's clonal selection theory, [113] which overlooks the contributions of Ehrlich, Jerne, Talmage, and the contributions of Lederberg, who conceptualised the genetics of clonal selection. [114] Burnet's work on graft-versus-host was in collaboration with Lone Simonsen between 1960 and 1962.
[a] Clonal selection theory (CST): hematopoietic stem cells (1) differentiate and undergo genetic rearrangement to produce a population of cells possessing a wide range of pre-existing diversity with respect to antibody expression (2). Lymphocytes expressing antibodies that would lead to autoimmunity are filtered from the population (3), while ...
In the late 1950s however, the works of three scientists—Jerne, Talmage and Burnet (who largely modified the theory)—gave rise to the clonal selection theory, which proved all the elements of Ehrlich's hypothesis except that the specific receptors that could neutralize the agent were soluble and not membrane-bound. [17] [30]
In theory, you can drive the Ramcharger without ever visiting an EV charging station, or you can skip traditional gas stations altogether. Better yet, there aren’t any downsides when it comes to ...
A hypothetical HIV vaccine concept based on immune network theory has been described. [23] The vaccine concept was based on a network theory resolution of the Oudin-Cazenave paradox. [24] This is a phenomenon that makes no sense in the context of clonal selection, without taking idiotypic network interactions into account.