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Dopamine may cause rapid heart rate and arrhythmias, and is only recommended in combination with norepinephrine in those with slow heart rate and low risk of arrhythmia. In the initial treatment of low blood pressure in septic shock, the goal of vasopressor treatment is a mean arterial pressure (MAP) of 65 mm Hg. [10]
Norepinephrine raises blood pressure through a vasoconstriction effect, with little effect on stroke volume and heart rate. [5] In some people, the required dose of vasopressor needed to increase the mean arterial pressure can become exceedingly high and it becomes toxic. [ 75 ]
The SOFA scoring system is useful in predicting the clinical outcomes of critically ill patients. [8] According to an observational study at an Intensive Care Unit (ICU) in Belgium, the mortality rate is at least 50% when the score is increased, regardless of initial score, in the first 96 hours of admission, 27% to 35% if the score remains unchanged, and less than 27% if the score is reduced. [9]
A common misconception among the public is that sepsis means bacteria in the blood, but any infection can cause sepsis, Rangaswamy said. A skin, lung or urinary tract infection can progress into ...
Begg says sepsis mortality in developed countries like the UK is about 15%, but warns that many surviving patients suffer from the consequences of sepsis, which can include amputated limbs, for ...
People with sepsis need preventive measures for deep vein thrombosis, stress ulcers and pressure ulcers, unless other conditions prevent such interventions. [4] Some might benefit from tight control of blood sugar levels with insulin .