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Soluble fluoride salts, of which sodium fluoride is the most common, are toxic, and have resulted in both accidental and self-inflicted deaths from acute poisoning. [4] The lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride per kg body weight).
Fluoride's suppressive effect on the thyroid is more severe when iodine is deficient, and fluoride is associated with lower levels of iodine. [clarification needed] [31] Thyroid effects in humans were associated with fluoride levels 0.05–0.13 mg/kg/day when iodine intake was adequate and 0.01–0.03 mg/kg/day when iodine intake was inadequate.
The dose that may lead to adverse health effects is about one fifth of the lethal dose. [69] Chronic excess fluoride consumption can lead to skeletal fluorosis, a disease of the bones that affects millions in Asia and Africa. [69] [70] The fluoride ion is readily absorbed by the stomach and intestines.
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[9] [10] Hexafluoride Solution has been used to mitigate the adverse effects of chemical burns and counteract the effect of calcium precipitation [11] [self-published source], due to the triple effect of rinsing and diluting like water, neutralization of the hydrogen ions and chelation of the fluoride ions. However, further studies have found ...
Skin absorption relates to the degree of exposure to and possible effect of a substance which may enter the body through the skin. Human skin comes into contact with many agents intentionally and unintentionally. Skin absorption can occur from occupational, environmental, or consumer skin exposure to chemicals, cosmetics, or pharmaceutical ...
Sodium fluoride (NaF) is an inorganic compound with the formula Na F.It is a colorless or white solid that is readily soluble in water. It is used in trace amounts in the fluoridation of drinking water to prevent tooth decay, and in toothpastes and topical pharmaceuticals for the same purpose.
Halogenodermas are skin eruptions that result after exposure to halogen-containing drugs or substances. This may last several weeks after drug use is discontinued. This is because of the slow elimination rate of iodides and bromides. [1] Fluoroderma is a particular type of halogenoderma which is caused by fluoride.