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In humans inorganic arsenic is reduced nonenzymatically from pentoxide to trioxide, using glutathione or it is mediated by enzymes. Reduction of arsenic pentoxide to arsenic trioxide increases its toxicity and bio availability, Methylation occurs through methyltransferase enzymes. S-adenosylmethionine (SAM) may serve as methyl donor.
Arsenic and its compounds, especially the trioxide, are used in the production of pesticides, treated wood products, herbicides, and insecticides. These applications are declining with the increasing recognition of the toxicity of arsenic and its compounds. [15] Arsenic has been known since ancient times to be poisonous to humans. [16]
Broadly, long-term exposure to toxic heavy metals can have carcinogenic, central and peripheral nervous system, and circulatory effects. For humans, typical presentations associated with exposure to any of the "classical" [37] toxic heavy metals, or chromium (another toxic heavy metal) or arsenic (a metalloid), are shown in the table. [38]
Inorganic arsenic is more toxic to humans than the naturally occurring form of the mineral arsenic, and the health effects from exposure are more severe, according to the U.S. Food and Drug ...
Methylnaphthalene, anthracene and pyrene can all be toxic to humans, according to the National Institutes of Health. Chromium, a chemical element/metal; some types of chromium can be toxic.
Arsenic is a moderately abundant element in Earth's crust, and although many arsenic compounds are often considered highly toxic to most life, a wide variety of organoarsenic compounds are produced biologically and various organic and inorganic arsenic compounds are metabolized by numerous organisms.
Inorganic arsenic is more toxic to humans than the naturally occurring form of the mineral arsenic, and the health effects from exposure are more severe, according to the U.S. Food and Drug ...
In humans, arsenic of these valences is readily absorbed by the gastrointestinal tract, which accounts for its high toxicity. Pentavalent arsenic tends to be reduced to trivalent arsenic and trivalent arsenic tends to proceed via oxidative methylation in which the trivalent arsenic is made into mono, di and trimethylated products by ...