Search results
Results From The WOW.Com Content Network
Metabolites of DHT have been found to act as neurosteroids with their own AR-independent biological activity. [ 19 ] 3α-Androstanediol is a potent positive allosteric modulator of the GABA A receptor , while 3β-androstanediol is a potent and selective agonist of the estrogen receptor (ER) subtype ERβ . [ 19 ]
5β-Dihydrotestosterone (5β-DHT), also known as 5β-androstan-17β-ol-3-one or as etiocholan-17β-ol-3-one, is an etiocholane (5β-androstane) steroid as well as an inactive metabolite of testosterone formed by 5β-reductase in the liver and bone marrow [1] [2] and an intermediate in the formation of 3α,5β-androstanediol and 3β,5β-androstanediol (by 3α-and 3β-hydroxysteroid ...
3β-Androstanediol is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of DHT (and by extension of testosterone). A determination of the circulating levels of 3β-androstanediol in humans found concentrations of 239 ± 76 pg/ml and 82 ± 45 pg/ml of the compound in normal ...
Androsterone is a metabolite of testosterone and dihydrotestosterone (DHT). In addition, it can be converted back into DHT via 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase , bypassing conventional intermediates such as androstanedione and testosterone, and as such, can be considered to be a metabolic intermediate in ...
3α-Androstanediol also known as 5α-androstane-3α,17β-diol and sometimes shortened in the literature to 3α-diol, is an endogenous steroid hormone and neurosteroid and a metabolite of androgens like dihydrotestosterone (DHT). [1] [2] [3]
Androstanedione, also known as 5α-androstanedione or as 5α-androstane-3,17-dione, is a naturally occurring androstane (5α-androstane) steroid and an endogenous metabolite of androgens like testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and androstenedione. [1] It is the C5 epimer of etiocholanedione (5β ...
In vitro and animal models suggest subsequent 3α-reduction of DHT, 5α-DHP and DHDOC lead to neurosteroid metabolites with effect on cerebral function. These neurosteroids , which include allopregnanolone , tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol , act as potent positive allosteric modulators of GABA A receptors , and ...
The discovery of the backdoor pathway to DHT biosynthesis in tammar wallaby pouch young prompted research into identifying and characterizing similar pathways in humans, leading to a better understanding of the regulation, metabolism, and therapeutic targeting of androgen biosynthesis in human health and diseases related to excessive or ...